منابع مشابه
Synthesis and estimations of antimicrobial properties of novel pyrazoline derivatives
Chalcones are the condensation product of acetophenone in combination with aromatic aldehydes in the presence of strong base. Chalcones and their metal complexes having prominent role in modern coordination chemistry. These compounds possessing novel structural features, interesting spectral and magnetic properties, have been the subject of intensive research due to their importance in medical,...
متن کاملSynthesis, Analgesic and Antimicrobial Activities of Some Novel Isoxazole Derivatives
Substituted aryl-N-chalconyl aminophenols 1a-f were synthesized by base catalysed condensation of equimolar mixture of N-(4-hydroxyphenyl)-acetamide and appropriate araldehydes. Treatment of compounds 1a-f with hydroxylamine hydrochloride in ethanol afforded a series of novel 4-(5′-substituted-aryl-4′,5′-dihydroisoxazole-3′-yl-amino) phenols have been synthesized by treating substituted aryl-N-...
متن کاملDesign, Synthesis and Antimicrobial Evaluation of Some Novel Quinoline Derivatives
The Global Burden of Disease Study(GBDS) estimates that infectious diseases were responsible for 22% of all deaths and 27% of disability-adjusted life years (DALYS ) worldwide according to WHO [1]. Antimicrobial resistance among clinically important bacteria is widely acknowledged as a major global public health threat [2]. Most of the currently used antimicrobial drugs are associated with adve...
متن کاملSynthesis and antimicrobial activity of some novel oxadiazole derivatives.
A series of 5-(3'-oxo-6'-(substituted aryl)-2',3',4',5'-tetrahydropyridazin-2'-ylmethyl )-2-substituted 1,3,4-oxadiazole has been synthesized. Appropriate aromatic hydrocarbon reacts with succinic anhydride in the presence of AICl3 to yield beta-aroyl propionic acid (1a). The corresponding acid is cyclized with hydrazine hydrate to give 6-(substituted aryl)-2,3,4,5-tetrahydro-3-pyridazinone (1b...
متن کاملSynthesis, Characterization and Antibacterial Activity of some Novel Thiosemicarbazides, 1,2,4-Triazol-3-thiols and their S-substituted Derivatives
The thiosemicarbazides 3a-c were appeared by reaction of the corresponding substituted hydrazides 1a-c with allylisothiocyanate 2. Synthesis of some novel 1,2,4-triazole-thiols 4a-c bearing a pyridyl unit using 1-(x-picolinoyl)-4-allyl-thiosemicarbazides (x = 2,3,4) in an alkaline solution, is reported. Also, the S-alkylation of triazole derivatives 5-7a-c is described. The structure of the syn...
متن کاملSynthesis, Characterization and Antibacterial Activity of some Novel Thiosemicarbazides, 1,2,4-Triazol-3-thiols and their S-substituted Derivatives
The thiosemicarbazides 3a-c were appeared by reaction of the corresponding substituted hydrazides 1a-c with allylisothiocyanate 2. Synthesis of some novel 1,2,4-triazole-thiols 4a-c bearing a pyridyl unit using 1-(x-picolinoyl)-4-allyl-thiosemicarbazides (x = 2,3,4) in an alkaline solution, is reported. Also, the S-alkylation of triazole derivatives 5-7a-c is described. The structure of the syn...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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